A “next generation” immunotherapy treatment that has the potential to cure leukaemia has been given NHS approval.
The treatment, known as Obe-cel, is a type of cell therapy developed in the UK and works by genetically modifying cells to enable the body’s own immune system to recognise and attack cancer.
The therapy, which only needs to be given once in a lifetime, was developed by Autolus, a University College London (UCL) spinout company.
The National Institute for Health and Care Excellence (Nice) has recommended obe-cel (also called Aucatzyl) in England for people aged 26 and over.
The watchdog said the treatment could help more than 150 people over the next three years who have relapsed or refractory B-cell acute lymphoblastic leukaemia (ALL), all with limited treatment options.
Obe-cel increases the likelihood of people going into remission and has fewer side effects, meaning more people could benefit from it compared to other treatments.
Evidence from a clinical trial has shown high rates of remission in patients whose cancer has either returned (relapsed) after treatment or failed to respond to initial therapy (refractory).
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A study of 94 people found over three quarters (77%) given the treatment went into remission.
More than half of those were then showing no signs of detectable cancer after three and a half years.
Another CAR T-cell treatment is available for people aged 25 and under.
B-cell acute lymphoblastic leukaemia is a rare blood cancer, affecting fewer than five in 10,000 people in the UK.
Helen Knight, director of medicines evaluation, at Nice, said the treatment “offers real hope to people living with this rare and aggressive blood cancer.”
She added: “This could potentially be a life-saving drug, which will make a huge difference to people’s lives, including spending less time in hospital.”
Harry Brown was treated with Obe-cel as part of a clinical trial in 2024. Credit: PA
Dr Claire Roddie, UCL Hospital consultant haematologist and associate professor at the UCL Cancer Institute, said: “I am delighted to hear of Nice’s decision.
“Many more patients now stand to benefit from this CAR T-cell therapy on the NHS and we are still working to widen its application.”
People receive two doses of the CAR T-cell treatment therapy intravenously, 10 days apart, with the treatment being delivered at selected specialist CAR T-cell centres across England.
Harry, a 19-year-old student from Harrogate, was treated with Obe-cel as part of a clinical trial in 2024.
He said: “I feel so lucky to have had access to such a wonderous treatment.
“Not only did it work better than my doctors thought it would, it worked without many of the horrible side effects you can get from other treatments.
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“The biggest thing it offers is hope. When you’re facing a situation like mine, hope is the most valuable thing you can have.”
Health minister, Ashley Dalton, said: “This pioneering treatment is excellent news for patients and their families, demonstrating how the NHS is at the forefront of medical innovation.”
Fiona Bride, interim chief commercial officer at NHS England, said the treatment represented “a success story that’s made in Britain”.
Fiona Hazell, chief executive at Leukaemia UK, said: “We are delighted that this therapy will be available on the NHS and this is a significant step forward in expanding treatment options for people living with leukaemia.”
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